PELS (Figure) is a revolutionary proteomics-based biomarker discovery platform that can be applied diversely to (i)  infectious diseases / conditions caused by pathogens or  commensals, be it a bacterium, fungus, virus or parasite; (ii) any condition that involves expression of differentially expressed proteins.  

 

The wide applicability of PELS and its iterations allow definition of functional immunoproteomes, circulatory “shed” proteomes / immunoproteomes, and Depletomes.